Role of methacholine challenge test in asthma epidemiological studies
نویسندگان
چکیده
منابع مشابه
Methacholine challenge: test-shortening procedures.
STUDY OBJECTIVES Validation of test-shortening procedures for the 2-min tidal breathing methacholine challenge method. DESIGN Retrospective chart review. SETTING Tertiary-care university clinical pulmonary function laboratory. PATIENTS One thousand subjects aged 10 to 85 years (mean +/- SD, 44.5 +/- 16.0 years), 44.5% male, referred for methacholine challenge. INTERVENTION Two-minute ti...
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Methacholine inhalation challenge has become an accepted test to determine the presence of airway hyperresponsiveness, a hallmark of asthma. To help physicians interpret the results of a methacholine challenge test in a clinical setting, we analyzed the test data of 1,105 subjects, asthmatics and nonasthmatics. Applying Bayes' theorem, a nomogram was constructed incorporating the prechallenge c...
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We investigated whether an exercise challenge protocol is suitable for measuring bronchial responsiveness in epidemiological studies of asthma in children, and determined its comparability with histamine challenge. The exercise challenge was 6 minutes of outdoor, free-range running at 85-90% of maximum heart rate, measured by heart rate monitor. Nose clips were worn. Distance run was measured t...
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A 20-year-old white female nonsmoker presented to the pulmonary function laboratory for a methacholine challenge test. The patient denied wheezing, dyspnea, cough, or chest tightness. In fact, she competes in collegiate basketball and softball without respiratory complaints. She stated that her primary care physician wanted to “screen her for asthma,” because her father is asthmatic. Her medica...
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It has been suggested that, in epidemiological studies, asthma should be defined as symptomatic bronchial hyperresponsiveness (BHR). This paper critically examines the validity of this and alternative methods of defining asthma by reviewing population-based studies validating BHR and symptom questionnaires against asthma defined on the basis of a clinical assessment. It is emphasized that a sin...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2020
ISSN: 1939-4551
DOI: 10.1016/j.waojou.2020.100208